Brain Injury, Traumatic
Basics
Description
- Traumatic brain injury (TBI) is defined as an alteration in brain function caused by an external force.
- Mild TBI (mTBI) is defined by Glasgow Coma Scale (GCS) score 13 to 15 and short-lived neurologic symptoms (loss of consciousness [LOC], posttraumatic amnesia, altered mental status [AMS], or transient neurologic deficit).
- System(s) affected: neurologic; psychiatric; cardiovascular; endocrine/metabolic; gastrointestinal; pulmonary
- Synonym(s): head injury, concussion
Epidemiology
Incidence
- Majority (>70%) of TBIs are mild.
- 2.87 million ED visits with 288,000 hospitalizations per year in the United States
- 56,000 TBI-related deaths per year; ~43% of patients who survive will experience long-term disabilities.
- Young children (ages 0 to 4) and older adults (≥75 years old) have highest incidence (1).
Etiology and Pathophysiology
- Centers for Disease Control and Prevention (CDC) TBI data in 2017, mechanism of injury of hospitalized patients (male vs. female percentage)
- Unintentional falls (35.6 vs. 23.9)
- Motor vehicle crashes (22.5 vs. 10.8)
- Unintentionally being struck by or against an object (2.3 vs. 0.9)
- Intentional self-harm (0.8 vs. 0.3)
- Assault (7.5 vs. 1.7)
- Children 0 to 17 years
- Falls (7.7)
- Motor vehicle crashes (6.8)
- Contact sports account for 45% of TBI emergency room visits for children related to sports and recreation.
- Mechanical damage with actuation of complex cellular and molecular cascades that promote cerebral edema, ischemia, and apoptotic cell death
Risk Factors
Alcohol and drug use, prior/recurrent head injury, contact sports, seizure disorderGeriatric Considerations
Subdural hematomas (SDHs) are common after a fall or blow in elderly; symptoms may be subtle and not present until days after trauma.
General Prevention
- Safety education and fall prevention
- Seat belts; bicycle and motorcycle helmets
- Banning certain types of contact in sports that carry increased risk of concussion
Geriatric Considerations
Learning about individual fall risk can help prevent injuries resulting in TBI for adults ≥75 years old.Pediatric Considerations
- Incidence is high in children age 0 to 4 due to falls and developing motor skills. Risk also increases in adolescence due to sports and motor vehicle accidents.
- Child abuse: Consider if dropped or fell <4 feet (e.g., off bed, couch), suspicious history, significant injury present, injury inconsistent with developmental age (e.g., rolling off bed in an infant), or any retinal hemorrhages.
There's more to see -- the rest of this topic is available only to subscribers.
Citation
Domino, Frank J., et al., editors. "Brain Injury, Traumatic." 5-Minute Clinical Consult, 35th ed., Wolters Kluwer, 2027. tabers.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/1688576/all/Brain_Injury__Traumatic.
Brain Injury, Traumatic. In: Domino FJF, Baldor RAR, Golding JJ, et al, eds. 5-Minute Clinical Consult. Wolters Kluwer; 2027. https://tabers.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/1688576/all/Brain_Injury__Traumatic. Accessed July 18, 2026.
Brain Injury, Traumatic. (2027). In Domino, F. J., Baldor, R. A., Golding, J., & Stephens, M. B. (Eds.), 5-Minute Clinical Consult (35th ed.). Wolters Kluwer. https://tabers.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/1688576/all/Brain_Injury__Traumatic
Brain Injury, Traumatic [Internet]. In: Domino FJF, Baldor RAR, Golding JJ, et al, eds. 5-Minute Clinical Consult. Wolters Kluwer; 2027. [cited 2026 July 18]. Available from: https://tabers.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/1688576/all/Brain_Injury__Traumatic.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Brain Injury, Traumatic
ID - 1688576
ED - Domino,Frank J,
ED - Baldor,Robert A,
ED - Golding,Jeremy,
ED - Stephens,Mark B,
BT - 5-Minute Clinical Consult, Updating
UR - https://tabers.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/1688576/all/Brain_Injury__Traumatic
PB - Wolters Kluwer
ET - 35
DB - 5-Minute Clinical Consult
DP - Unbound Medicine
ER -

5-Minute Clinical Consult

